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Wellness since 1983

Ayugen Anti-Clotting Treatment

Ayugen Anti-Clotting Treatment Guidance Test

Warfarin is an anti-clotting agent prescribed for patients with irregular heartbeat, heart attack, heart valve replacement surgery, stroke, major surgeries or clotting disorders. The optimal Warfarin dose depends on the patient’s diet, age, genetic variants, and the use of other medications. Patients with genetic variants require twice the number of days for stabilization of Warfarin dose as compared to those without any variations. Because of the risk of severe bleeding Warfarin is probably under-prescribed. At AyuGen Biosciences we perform a test to predict the sensitivity of an individual to Warfarin, before the drug is prescribed. We test for genetic markers in 2 genes, CYP2C9 and VKORC1, which are associated with Warfarin’s metabolism and site of action respectively.

The test will help predict an individual’s response to Warfarin and aid doctors in quickly and accurately establishing the correct dose thus:

  • Enabling clinicians to provide safer, more effective and individualized treatment to their patients by knowing patient’s sensitivity status before starting the Warfarin treatment
  • Decreasing risk of inappropriate dosing during induction of therapy
  • Reducing the risk of serious side effects, including life-threatening bleeding
  • Reducing time to achieve stable INR
  • Giving a more careful monitoring system and advice (including dietary) for sensitive patients.

The use of this test does not eliminate the need for monitoring PT as clinically indicated. It is still important to ensure the correct dose of Warfarin is being administered based on the target PT or INR.

This is not a diagnostic test. This test does not test for any genetic mutations responsible for causing Warfarin resistance. It is possible that the individual may have Warfarin sensitive mutations tested above but still require a higher dose of Warfarin because of the presence of mutations that confer Warfarin resistance.

This test is recommended for all individuals

  • Who are currently on warfarin therapy
    1.To explain the specific response of a patient to warfarin; and thereby avoid complications in the future
  • At the beginning of warfarin therapy
    1. To help reduce adverse events like bleeding complications, etc.
    2. To reduce the time taken to achieve stable INR